Aneesh Kumar Pillai, a discus thrower, was forced to withdraw from his Birmingham Games competition after testing positive for COVID-19 on Wednesday.
It was planned for Pillai to compete in the F44 discus throw championship.
"He has a COVID positive test but no symptoms. Due to his CT value being on the upper side, the CGF did not clear his participation. He had his final today, so that is terribly terrible, a senior officer of the Indian contingent told PTI.
At the Para Asian Games in Jakarta four years ago, Pillai won a bronze medal.
The Commonwealth Games para events are taking place at the same time as competitions for athletes with physical disabilities.
Navjot Kaur, a player for the women's hockey team, had to travel home earlier after being ill with the illness.
S Meghana and Pooja Vastrakar, two Indian women's cricket players, tested positive in India before the Games; nevertheless, they have since joined the team in Birmingham.
The other Indians competing in the discus throw are Devender Gahlot and Devender Kumar.